Despite these results, the NPV of ELF alone did not exceed 85% in our sample, in which the prevalence of advanced fibrosis of was approximately 25% among patients with liver biopsy, which is close to that seen by hepatologists in their daily practice,21 and evidence from prior studies suggests that the use of 2 or more NITs may be associated with improved diagnostic accuracy. The gene discussed is SPTBN1; the disease is fibrosis.