The recurrence and metastasis of HNSCC are facilitated by immune evasion,26 which is mediated in part by the expression of programmed death‐ligand (PD‐L1 and PD‐L2), which binds to the T‐cell suppressive immune checkpoint receptor PD‐1.22, 27. The gene discussed is PDCD1LG2; the disease is head and neck squamous cell carcinoma.