As a first test case for our approach, we chose the well‐characterized GBM cell culture U3065MG, derived from a 77‐year‐old male patient. U3065MG cells classify as mesenchymal subtype, are TP53 and IDH1 wild type, form infiltrative macroscopic tumors in vivo, and harbor a subset of clonogenic cells that can give rise to both primary and secondary cultures (Xie et al, 2015; Segerman et al, 2016). This evidence concerns the gene TP53 and glioblastoma.