DROSHA and Alzheimer disease: In addition, loss of Drosha precedes activation of caspase‐3 triggered by Aβ oligomers in cultured neurons and occurs in 8‐month TgF344‐AD rats before the reported significant neuronal loss at 16 month (Cohen et al., 2013) while overexpression of Drosha protects neurons from Aβ oligomers‐induced toxicity.