Currently no WASH variants have been reported to directly associate with the PD but several variants on WASH complex subunit, such as strumpellin, have been reported to associate with other neurodegenerative diseases, including hereditary spastic paraplegia (HSP), sporadic amyotrophic lateral sclerosis and frontotemporal lobar degeneration (ALS/FTD) [59–63]. This evidence concerns the gene WASHC1 and neurodegenerative disease.