To eliminate the possibility that the loss of Prlr in the brain might cause exaggerated stress responses in the pregnant females (Slattery and Neumann, 2008; Torner et al., 2001) that could influence acute RWA (Malisch et al., 2016), we also examined anxiety-like behavior in late pregnant (day 15/16) Prlrlox/lox/Camk2aCre and control mice using the EPM, as described previously (Ladyman et al., 2018b). The gene discussed is PRLR; the disease is Anxiety.