Therefore, to clarify the effect NPRC exerts on adipose inflammation accompanied with atherosclerosis, we generate NPRC−/−ApoE−/− mice to construct atherosclerotic models to explore adipose phenotype, metabolism and inflammation compared with ApoE−/− mice, which not only uncover the roles NPRC plays in adipose inflammation, but also may provide new views for preventing atherosclerosis. This evidence concerns the gene NPR3 and atherosclerosis.