IGF‐1activates the Rho/Rho‐kinase pathway and elevates the formation of stress fibres by inhibiting the ectopic expression of the postsynaptic density protein 95/ discs‐large / zona occludens 1 and regulator of G protein signalling domains of leukaemia‐associated Rho guanine nucleotide exchange factor.42 This evidence concerns the gene RHO and leukemia.