LCN2 and X-linked dominant hypophosphatemic rickets: However, even if post-exercise osmolality-corrected uNGAL concentrations were significantly greater in HYP, this would not necessarily be indicative of an increase in injury to the distal nephron, as a decrease in the proximal tubular reabsorption of NGAL can also contribute to a rise in uNGAL (Kashani et al. 2017; Schlader et al. 2019).