SGK1 and pulmonary arterial hypertension: In particular, Sgk1 showed an up-regulation in ECs corresponding to arterioles/pre-capillary vessels, vasculature which is particularly affected by remodelling and neomuscularization in PAH.7 Since Sgk1 regulates angiogenesis55 and Sgk1 deficiency prevents hypoxia-induced PAH in mice,56Sgk1 appears to be a key regulator of the primary changes occurring in ECs.