CDH5 and Right ventricular hypertrophy: We confirmed a significant increase in RVSP and right ventricular hypertrophy in PAH compared with Control mice for both the Cdh5-CreERT2-TdTomato and C57BL/6 lines (Supplementary material online, Figure S2A) and a significant increase in the proportion of fully remodelled vessels in PAH C57BL/6 mice (Supplementary material online, Figure S2B).