The results revealed significant changes including the increased expression of tumorigenesis-related markers, such as CD133, Bmi-1, VEGF, MMP-3, IL-1β, IL-6, TNF-α, and MDR, as well as the apoptotic markers, Bax and Bcl-xL, in the REM134-driven tumor group. The gene discussed is MMP3; the disease is neoplasm.