TNF and atherosclerosis: Additionally, the KEGG pathways were most enriched in immune- and inflammatory-associated pathways, including the MAPK signaling pathway (hsa04010), IL-17 signaling pathway (hsa04657), TNF signaling pathway (hsa04668), Toll-like receptor signaling pathway (hsa04620), and C-type lectin receptor signaling pathway (hsa04625), and involved in angiogenesis and atherosclerosis pathways: fluid shear stress and atherosclerosis (hsa05418) and relaxin signaling pathway (hsa04926).