For instance, researches indicated that quercetin mediate the anti-inflammatory mechanism of reducing acute laryngitis by restoring the Th17/Treg balance and activating heme oxygenase 1 and isorhamnetin increased the levels of TNF-α, IL-1β, IL-6, IL-17A, and IL-17F as well as decreased levels of IL-35 and IL-10 in the CIA mice, resulting in an anti-inflammatory effect [43, 44]. Here, HMOX1 is linked to acute laryngitis.