TNFSF10 and heart failure: Recently, death receptor (DR; also called TRAIL-R2, TNFRSF10B) 5 and its ligand, TNF-Related Apoptosis-Inducing Ligand (TRAIL; also called Tnfsf10, APO2L, and CD253), have been linked to multiple forms of human heart failure, although the function of DR5 in the heart is poorly understood (7–9).