It has been elucidated that the master antioxidant transcriptional factor (Nrf2) could down-regulate the expression of the TMPRSS2 in prostate cancer cell lines, thus causing alternations in the protease/antiprotease components balance and subsequently, and result in protection against the respiratory infections (Meyer and Jaspers, 2015). Here, TMPRSS2 is linked to Familial prostate cancer.