TNF and obesity due to melanocortin 4 receptor deficiency: After supplementation KPE at a dose of 50 mg/kg bw, the content of TNF-α and IL-1β had slightly decreased, but had no significantly difference compared to HDF group (P > 0.05), while at high dose supplementation (100 mg/kg bw) the content of TNF-α and IL-1β was decreased, had significantly difference compared to obesity rats (P < 0.05).