For example, the high levels of SMC1B, SMC2, and SMC3 expression were significantly associated with the T stage of HCC patients, the high levels of SMC2, SMC3, and SMC4 expression were significantly associated with the N stage of HCC patients, and the high levels of SMC2 expression was significantly associated with the M stage of HCC patients. The gene discussed is SMC3; the disease is hepatocellular carcinoma.