GPT and liver disorder: For patients in “real immune tolerance” period (positive HBeAg, normal ALT,HBV-DNA > 107-108 IU/ml, age <30 years, no or mild inflammation/fibrosis in the liver) and without extrahepatic diseases, antiviral treatment can be postponed for the low risk of liver disease progression, and the most important intervention are comprehensive professional follow-up and monitoring.