Moreover, the expression of ferroptosis markers, cyclooxygenase 2 (Cox2) and glutathione-specific γ-glutamylcyclotransferase 1 (Chac1), was upregulated, while the expressions of GPX4 and ferroptosis suppressor protein 1 (Fsp1) were downregulated in mice with streptozotocin-induced type 1 diabetes (T1D) (Zang et al., 2020). Here, AIFM2 is linked to type 1 diabetes mellitus.