In summary, we show here that the ferroptosis driver SOCS1 and suppressor FTH1 served as independent prognostic factors that independently correlate with M1 and M2 macrophage infiltration in HNSCC, suggesting that inducing ferroptosis directly influences the infiltration of M1–M2 macrophages. This evidence concerns the gene SOCS1 and head and neck squamous cell carcinoma.