The significantly higher SOCS1 and FTH1 mRNA levels in HNSCC compared with those in normal tissues were validated using the datasets GSE2379 (SOCS1, t = 3.569, p = 0.0010; FTH1, t = 3.168, p = 0.003), GSE3524 (SOCS1, t = 2.332, p = 0.0315; FTH1, t = 4.362, p = 0.0004), GSE6791 (SOCS1, t = 5.449, p < 0.0001; FTH1, t = 4.153, p = 0.0001), and PMID14729608 (SOCS1, t = 4.217, p < 0.0001; FTH1, t = 5.917, p < 0.0001) (Figure 3A). The gene discussed is FTH1; the disease is head and neck squamous cell carcinoma.