In addition, insulin-like growth factor 1 (IGF1) / insulin-like growth factor 1 receptor (IGF1R) signaling pathway has been demonstrated to be essential for the process of insulin resistance, which leading to metabolic diseases and type 2 diabetes (Fernandez et al., 2001; Le Roith et al., 2002). Here, IGF1 is linked to type 2 diabetes mellitus.