The expression of the MALAT1 was significantly upregulated in the cortex of sporadic FTD patients and binds to TDP-43 that interacts with several other lncRNAs, including lnc-BDNFOS and lnc-TFEB α (in SHSY5Y cells) and lnc-Myolinc (in muscle cells) (Militello et al., 2018). This evidence concerns the gene TARDBP and frontotemporal dementia.