Lnc-EBF3-AS was maladjusted in late-onset AD patients (Magistri et al., 2015), its upregulation was detected to stimulate the expression of EBF3 in the hippocampus of the AD transgenic mouse model, thus promoting the apoptosis of neurons in AD (Gu et al., 2018). This evidence concerns the gene EBF3 and Alzheimer disease.