TARDBP and amyotrophic lateral sclerosis: In view of the different interactions between TDP-43/FUS and lncRNAs, the cytoplasmic mislocalization and dysfunction of TDP-43 and FUS in ALS may affect the distribution, expression and/or function of lncRNAs, thereby leading to degeneration and ALS of MN (Lo Piccolo and Yamaguchi, 2017).