In view of the fact that proteasome degradation is affected in HD (Hirose et al., 2014; Hyrskyluoto et al., 2014) and that NEAT1 level is elevated in HD (Makhlouf et al., 2014), it could be inferred that Neat1 may affect proteasome degradation in HD. The gene discussed is NEAT1; the disease is Huntington disease.