CD33 and non-small cell lung carcinoma: Liang and Shen (2020) proved that LXR agonists GW3965 and RGX-104 enhanced antitumor immune responses and improved radiosensitive effects of non-small cell lung cancer (NSCLC) by reducing the level of tumor-infiltrating MDSCs induced by radiotherapy. CD33 is highly expressed on MDSCs in humans, Fultang et al. (2019) found that the combination of the anti-CD33 monoclonal antibody gemtuzumab and the immunotoxin ozogamicin nicely eliminated CD33+ MDSC, providing a novel strategy in targeting MDSCs treatment.