JPH2 and hydrops fetalis: In response to cardiac stress and aging, also miR-34a increases (Boon et al., 2013) and targets the critical Ec-coupler, Junctophilin 2 (Jph2) (Hu J. et al., 2019) and Phosphatase 1 nuclear targeting subunit (PUNTS), causing myocardial insufficiency and progressive HF (Boon et al., 2013).