Overexpression of miR-99a attenuates cardiac hypertrophy in transverse aortic constriction (TAC) mice and in isoprenaline (ISO)/angiotensin-II (Ang II)-induced hypertrophic cardiomyocytes through downregulation of hypertrophic mammalian target of rapamycin (mTOR) signaling pathway (Li et al., 2016). The gene discussed is AGT; the disease is cardiac hypertrophy.