Furthermore, Hao et al, highlighted its role in preventing atherosclerosis progression through the targeting of mitogen-associated protein kinase (MAPK) signaling pathway in THP-1 cells (Hao and Fan, 2017), and Schober et al. demonstrated that miR-126-5p delays atherosclerotic plaques formation by reducing endothelium damage through suppression of the Notch1 inhibitor, Delta-like 1 homolog (Dlk1), which promotes ECs proliferation. This evidence concerns the gene NOTCH1 and atherosclerosis.