NOTCH1 and neoplasm: Recently, in an in vitro model of triple negative breast cancer, poly (lactic-co-glycolic acid) (PLGA) NPs loaded with miR-34a mimics and Notch1 antibodies are able to stop tumor growth by inhibiting Notch1 signaling and by miR-34a-mediated activation of tumor suppressive genes (Valcourt and Day, 2020).