According to the Venn diagram, 6 genes were located in both the interaction group and the correlated list, including BUB1, CCNA2, CCNB1, CDK1, MAD2L1 and PLK1. Then we profiled the tissue-wise expression of the 6 intersection genes in different cancer types using an interactive heatmap by GEPIA2 (Figure 6D). This evidence concerns the gene BUB1 and cancer.