S100A8/A9 secreted by monocytes can induce pancreatic tumor cells to secrete proinflammatory cytokines, including IL-8, fibroblast growth factor (FGF), and tumor necrosis factor-alpha (TNF-α), mediated in part by RAGE in pancreatic tumor cells. The gene discussed is CXCL8; the disease is pancreatic neoplasm.