treated human pancreatic cancer Capan-1 cells with different concentrations of dexmedetomidine (Dex) and demonstrated for the first time that Dex inhibits the proliferation of PC cells and promotes cell apoptosis by upregulating the expression of miR-526b-3p and inhibiting the expression of S100A4 (163). This evidence concerns the gene S100A4 and pachyonychia congenita.