S100A8/A9 secreted by monocytes can induce pancreatic tumor cells to secrete proinflammatory cytokines, including IL-8, fibroblast growth factor (FGF), and tumor necrosis factor-alpha (TNF-α), mediated in part by RAGE in pancreatic tumor cells. Here, IGKV1D-22 is linked to pancreatic neoplasm.