NPM1 and acute myeloid leukemia: Work-up lead to a diagnosis of AML with normal karyotype; molecular studies (Myeloid NGS) revealed variants in NPM1 (Type A mutation, p.Trp299Cysfs*12, 40% VAF), NRAS (p.Gly13Asp, 42% VAF) and IDH2 (p.Arg140Gln, 45% VAF).