CD274 and neoplasm: Although some studies have shown that the high expression of PD-L1 promotes tumor cells epithelial-mesenchymal transition and metastasis, leading to a poor prognosis (32), a meta-analysis showed that PD-L1 expression does not affect the prognosis (33), therefore, there is no difference in the expression of PD-L1 between the high- and low-risk groups, and it does not mean that the PD-1 immunotherapy have the same efficacy in the two groups.