The dysregulated expression of BMP1, BMP7, CALD1, KRT14, CAV2, IL1RN, and adherent junctions proteins (CDH1, CDH2, DSC2), promotes the primordial detachment between the distal cancer cells, depriving the central cancer cells of the blood supply leading to comedonecrosis in AC and LCNEC and “geographic” in SCLC. The gene discussed is CALD1; the disease is small cell lung carcinoma.