Furthermore, 12 genes (BMP1, BMP7, CALD1, CDH1, COL3A1, COL5A2, EGFR, ERBB3, PLEK2, SNAI2, STEAP1, and TCF4) were differentially expressed among histological subtypes and were all overexpressed in SCLC and LCNEC when compared to TC and AC. The gene discussed is STEAP1; the disease is large cell neuroendocrine carcinoma.