Furthermore, 12 genes (BMP1, BMP7, CALD1, CDH1, COL3A1, COL5A2, EGFR, ERBB3, PLEK2, SNAI2, STEAP1, and TCF4) were differentially expressed among histological subtypes and were all overexpressed in SCLC and LCNEC when compared to TC and AC. This evidence concerns the gene COL3A1 and large cell neuroendocrine carcinoma.