HHV8+ MCD is a waxing and waning febrile illness, commonly occurring in immunocompromised populations (e.g. HIV+), characterized by diffuse lymphadenopathy, splenomegaly, and anemia [6]. iMCD does not have a known pathogenesis, however, it is associated with high levels of IL-6. The gene discussed is IL6; the disease is anemia (phenotype).