In a prenatally stressed environment, as described above, or in pathological conditions such as Alzheimer’s or Parkinson’s disease, it is possible that EVs act as active mediators in the progression of AD and PD, by spreading the characteristic misfolded proteins like tau and Aβ in AD or like α-synuclein in PD [204, 205]. The gene discussed is MAPT; the disease is Alzheimer disease.