MAPT and Alzheimer disease: Taken together, the evidence for enrichment of Aβ-oligomer and Tau in EVs from AD patient brains, as well as evidence cited previously showing that maternal auditory stress significantly increases Aβ plaques in affected young-adult offspring, supports a hypothesis that EVs play a crucial mediating role in AD pathology, and in transducing the effects of early life experiences into early-onset AD pathology.