A study surveying mitochondrial signatures such as ATP5A, MTCOI, NADH, NDUFB8, NDUFS3, SDHB, UQCRC2 in blood-derived small EVs from PD and non-PD controls advocated that EVs may provide potential biomarkers in PD diagnosis and aid identification of potential targets for personalized medicine [72]. The gene discussed is NDUFB8; the disease is Parkinson disease.