A study surveying mitochondrial signatures such as ATP5A, MTCOI, NADH, NDUFB8, NDUFS3, SDHB, UQCRC2 in blood-derived small EVs from PD and non-PD controls advocated that EVs may provide potential biomarkers in PD diagnosis and aid identification of potential targets for personalized medicine [72]. Here, SDHB is linked to Parkinson disease.