Goetzl et al has described that the level of neurofunctional protein, including annexin VII, UCH-L1, occludin, aquaporin 4 and synaptogyrin-3, in plasma NDE were elevated in the acute mTBI phase but mostly normalized in chronic phase while they observed sustained abnormal increase in pathogenic proteins, such as Aβ42 and p-tau181, in chronic mTBI patients [43]. This evidence concerns the gene AQP4 and concussion.