CHMP5 and hereditary elliptocytosis: Whereas such signals might also result from antigenic drift (Jo, Drosten, and Drexler, 2021; Kistler and Bedford, 2021), previous data showing co-evolution of the spike protein with HE (Bakkers et al., 2017; Lang et al., 2020) suggest that optimization for human cell infection contributed to the evolution of this virus.