ICAM1 and Disorder of lipid metabolism: The results of our previous studies have shown that the compound Shoushen granules, a Traditional Chinese Medicine for tonifying the kidney, can significantly downregulate the serum lipid content of ApoE−/− mice induced by a high-fat diet to regulate their lipid metabolism disorders and reduce Toll-like receptor 4 (TLR4), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemotactic protein-1 (MCP-1) to improve the inflammatory response [26].