TP53 and cancer: Chloroquine caused the secretion of prostate apoptosis response-4 (Par-4) from wild-type p53 MEFs (Figure 2), as well as from normal human prostate stromal and lung fibroblast cells and their respective aminoquinoline derivatives, and induced Par-4 systemic secretion in C57BL/6 mice in a dose of 50 mg/kg body weight, and in patients from a clinical trial against cancer prior to surgery taking hydroxychloroquine [88].