The absence of DNA damage induced by chloroquine similar to DNA damage by direct ionizing radiation with consequent activation of p53 can be associated with its mechanism of interaction with DNA molecules, since chloroquine intercalates into DNA, but does not cause DNA damage directly [43, 49]; this does not exclude that caspase-3 activation is stronger in wild-type p53 glioma cells, proposing a clear contribution of p53 to chloroquine-induced apoptosis [43]. Here, TP53 is linked to central nervous system cancer.