On the other hand, chloroquine failed to alter protein levels of TP53, E2F1, CCND1, and HSPA1A in A375 cells, demonstrating that the chloroquine treatment was not associated with the induction of cell cycle arrest, a finding extremely different from amodiaquine-induced melanoma cell cycle obstruction in the S phase [57]. This evidence concerns the gene CCND1 and melanoma.