TP53 and glioblastoma: Moreover, chloroquine activation of ataxia telangiectasia-mutated (ATM)/ataxia telangiectasia and Rad3-related (ATR) kinase DNA injuries [45] seems unnecessary for caspases and p53 activation [37, 43, 44, 46–48], suggesting that aminoquinolines induce the death of glioblastoma cells, regardless of the p53 status [37].