A screening chemical library of antimalarial drugs against melanomas showed the endoperoxide-based redox antimalarial artemisinin-class members as inducers of apoptosis, while metastatic melanoma cells (A375, G361, and LOX) displayed a specific vulnerability to artemisinin and semisynthetic artemisinin-derivatives and NOXA-dependent apoptosis [82], a proapoptotic member of the Bcl2 family. Here, PMAIP1 is linked to melanoma.