The binding efficacy of seven different miRNAs (miR-1297, miR-26a-5p, miR-26b-5p, miR-4465, miR-142-5p, miR-5590-3p, and miR-561-3p), which are predicted to bind UCHL3 at rs2274048, is predicted to be weaker when the allele G is present, which would result in upregulation of UCHL3. This gene is involved in PC progression, and the highly expressed UCHL3-FOXM1 axis plays an important role in the oncogenesis and gemcitabine resistance (Song et al., 2019). The gene discussed is UCHL3; the disease is pachyonychia congenita.