Mice immunized with CDC25B (mean, 1.1 ± 1.4 tumors) or COX2 peptides (mean, 1.4 ± 1.8 tumors) developed significantly fewer colon tumors as compared to the control (mean, 6.3 ± 2.8 tumors p<0.0001 for all; Figure 5A). The gene discussed is CDC25B; the disease is colonic neoplasm.