We examined the phenotype of the tumor infiltrating T-cells in lesions that persisted after vaccination and observed that CD8+ T-cell levels were increased by 10-fold in tumors when the mice were immunized with the CDC25B peptide vaccine and by 16-fold after immunization with the COX2 peptide vaccine as compared to the control (p<0.001; Figure 5B and Supplementary Figure 4). This evidence concerns the gene CDC25B and neoplasm.