FAS and infection: Furthermore, monocytes from HSV-2 infected Fas (lpr) and FasL (gld)- deficient mice underwent delayed apoptosis and produced significantly less CXCL9, CXCL10 and TNF-α than monocytes in the wild type mice (17), which resulted in impaired recruitment of NK, CD4+ and CD8+ T cells within the infection sites followed by delayed virus clearance from the vaginal tissue and increased mortality (17).