Interestingly, our findings confirmed again that insulin is the key autoantigen for T1D initiation, since the administration of DQ4 not only eliminated peripheral mInsA2-10-autoreactive T cells response but also reduced the subsequent infiltration of CD4+ T and CD8+ T cells as well as inflammatory responses in the pancreas in NOD.β2mnull.HHD mice. This evidence concerns the gene CD8A and type 1 diabetes mellitus.