The density of FOXP3+ TILs (TILsFOXP3) in ICC tumor samples was 15.7 ± 14.8/field, which is significantly higher than that in para-tumor liver tissues (4.8 ± 5.3/field, P <.001, Figure 2B) and lower than CTLA-4 (P <.001, Figure S3A). The gene discussed is CTLA4; the disease is intrahepatic cholangiocarcinoma.