FOXP3 and immune system disorder: Here, we show that both hyperactivated CTLA-4 and FOXP3 are related to an unfavorable prognosis, and the amount of CTLA-4+ TILs is higher than FOXP3+ Tregs, which indicates that besides FOXP3+ Tregs, other CTLA-4+ TILs may be involved in antitumor immune disorders.