FOXP3 and neoplasm: As for the FOXP3 expression level in the four groups’ patients, TumorPD-L1 High/TILsCTLA-4 Low patients have a higher level of Tregs compared with TumorPD-L1 Low/TILsCTLA-4 High patients (P <.001, Figure S3B), and integrally, TumorPD-L1 High patients are prone to have more Tregs infiltrating into the ICC tumor than TumorPD-L1 Low patients (P <.001, Figure S3C).