The GO and KEGG enrichment analyses showed most of the 25 genes in the signature are involved in various immune-related biological processes/pathways, such as “B cell receptor signaling pathway,” “antigen receptor-mediated signaling pathway,” “immune response-activating cell surface receptor signaling pathway,” “receptor ligand activity,” implying that membrane receptor-mediated immune signaling cascade is one of the key determinants of the sensitivity to paclitaxel and anthracycline-based neoadjuvant chemotherapy in breast cancer. The gene discussed is CD177; the disease is breast carcinoma.