FTO, prompted by metabolic stress and starvation through the NF-κB signaling pathway and autophagy, increases melanoma growth and decreases response to anti-PD-1 blockade immunotherapy by protecting tumor cell-intrinsic genes (PD-1 (PDCD1), CXCR4 and SOX10) mRNA from decaying. This evidence concerns the gene PDCD1 and melanoma.