Unlike the phenotype of the Clk1 knockout mice reported here, overexpression of CLK2 in the mediobasal thalamus can partially reverse the HFD-induced obese phenotype in mice (Quaresma et al., 2017), and mice lacking Clk2 in adipose tissue exhibited exacerbated obesity (Hatting et al., 2017). This evidence concerns the gene CLK1 and Obesity.