In addition, some studies have shown that MDR1 promoted the excretion of bilirubin and bile acid, and accelerated the efflux of hepatotoxic substances, so as to dispel jaundice, cholagogic and detoxification, thereby regulating bile acid metabolism (Tang et al., 2016; Jetter and Kullak-Ublick, 2020). The gene discussed is ABCB1; the disease is Jaundice.