In addition, because there are many studies on the role of IL-1β in depression, there are relatively few studies on IL-18, another effect product of the NLRP3 inflammasome, exactly what role IL-18 can play in the pathogenesis of depression and whether there is an interaction between IL-1β and IL-18 is still inconclusive. The gene discussed is IL1B; the disease is depressive symptom measurement.