One of NLRP3 inflammasome has been shown to be involved in the development of a variety of inflammatory-related diseases, such as type 2 diabetes (Vandanmagsar et al., 2011), gout (Dalbeth et al., 2021), atherosclerosis (Karasawa and Takahashi, 2017), neurodegenerative diseases (Freeman and Ting, 2016), cancer (Zhiyu et al., 2016), and inflammatory bowel disease (Opipari and Franchi, 2015). The gene discussed is NLRP3; the disease is atherosclerosis.