It has been demonstrated that NLRP3 activation and formation of NLRP3 inflammasome in microglia surrounding hematoma after intracerebral hemorrhage promotes caspase-1 activation and leads to increased expression of IL-1β/IL-18, inducing and exacerbating aseptic inflammatory response (Ma et al., 2014; Feng et al., 2015; Yang et al., 2015; Yuan et al., 2015). Here, NLRP3 is linked to hematoma.