NLRP3 and major depressive disorder: Clinical studies (Alcocer-Gómez et al., 2014) found that the components of NLRP3 inflammasome and the effect product IL-1β of peripheral blood mononuclear cells in patients with depression were significantly higher than those of normal people, and these abnormal indicators will gradually become normal after receiving antidepressant treatment, the results of this study clearly show the relationship between depression and NLRP3.