Both NADPH and Apocynin inhibit the expression of NLRP3, ASC, caspase-1, IL-1β, and IL-18 in the ischemic cerebral cortex in a rat cerebral infarction model, and reduce the volume of cerebral infarction, improve survival after infarction, and restore neurological function (Qin et al., 2018). This evidence concerns the gene IL18 and cerebral infarction.