Studies have suggested that intermittent fasting, intravenous immunoglobulin, minocycline, emodin, tyrosine kinase can all inhibit the activation of NLRP3 inflammasome in cerebral ischemia-reperfusion (Fann et al., 2014; Zhang et al., 2015b; Leff-Gelman et al., 2016; Lu et al., 2016). The gene discussed is NLRP3; the disease is brain ischemia.