VEGFA and rheumatoid arthritis: Figure 7 shows the 20 most significant signaling pathways. According to these results, the most important pathways associated with the effects of O. vulgaris on RA treatment were the PI3K-Akt, HIF-1, VEGF, estrogen, MAPK, Fc epsilon RI, Rap1, FoxO, and Prolactir signaling pathways, suggesting that these pathways mediated the effect of O. vulgaris on RA.