ICAM1 and obesity due to melanocortin 4 receptor deficiency: Obesity is strongly associated with chronic metabolic inflammation (Hotamisligil, 2006; Lumeng et al., 2007) and celastrol distinctively inhibits inflammatory diseases (Kannaiyan et al., 2011; Guo et al., 2017); and so we investigated the anti-inflammatory activities of a panel of commercially available pentacyclic triterpenoids, that present structural similarity with celastrol, through their impact on lipopolysaccharides induced expression of intercellular adhesion molecule-1 (ICAM-1) in human microvascular endothelial cells (HMEC-1) (Zhang et al., 2018).