MAPT and Alzheimer disease: Indeed, have been found high similarities between human and degus ApoE, Amyloid β, and tau proteins (Salazar et al., 2016; Steffen et al., 2016; Hurley et al., 2018), reasons why degus is considered a natural model of AD-like pathology (Inestrosa et al., 2005; Cisternas et al., 2018).