NFE2L2 and neoplasm: Notably, the mRNA levels for Nqo1 in tumor and peri-tumoral tissues in WT (i.e. Gstp−/−: ApcMin/+: Nrf2+/+: Keap1+/+) mice were highly variable among 12 randomly selected individual animals (Fig. 3e), suggesting no consistent changes in Nrf2-transcriptional activity during adenoma development.