Curiously, we found that anemia was more prevalent in Keap1-KD animals than in any of the other three genotypes (p < 0.001 for Keap1-KD vs. WT; p = 0.012 for Keap1-KD vs. Nrf2-KO; p = 0.005 for Keap1-KD vs. Nrf2-KO/Keap1-KD). This evidence concerns the gene NFE2L2 and anemia (phenotype).