Consistent with the lack of effect of genetic Nrf2 activation by Keap1 knockdown, chronic intervention with TBE-31 (5 nmol/g body weight, orally, 3 days per week for 12 weeks, starting at week 8 of age) did not affect tumor development in Gstp+−/+−: ApcMin/+ mice. This evidence concerns the gene NFE2L2 and neoplasm.