SAMMSON is a target of the lineage-specific transcription factor SOX10. Importantly, SAMMSON silencing reduced melanoma cell growth and survival independently of the mutation state of BRAF, NRAS, or p53. Furthermore, SAMMSON silencing produced a response in BRAF inhibitor resistant melanoma cells and phenocopied the effects of downregulation of mitochondrial metabolism protein p32, causing dysfunction of mitochondria and resulting in tumor annihilation24. The gene discussed is SOX10; the disease is neoplasm.