SOX10 and melanoma: SAMMSON is a target of the lineage-specific transcription factor SOX10. Importantly, SAMMSON silencing reduced melanoma cell growth and survival independently of the mutation state of BRAF, NRAS, or p53. Furthermore, SAMMSON silencing produced a response in BRAF inhibitor resistant melanoma cells and phenocopied the effects of downregulation of mitochondrial metabolism protein p32, causing dysfunction of mitochondria and resulting in tumor annihilation24.