To further investigate the relationship between PITX1, SOX9 and SOX10 expression and clinical prognosis, we used RNA-seq datasets (GSE46517, GSE15606, and the cancer genome atlas [TCGA]-SKCM) from the Gene Expression Omnibus (GEO) and TCGA database to measure the expression level of these genes in melanoma primary, metastatic, and normal skin tissue. Here, SOX10 is linked to cancer.